CVT-12012

CVT-12012 is a potent and orally bioavailable stearoyl-coA desaturase (SCD) inhibitor, with IC50s of 38 nM, 6.1 nM for rat microsomal and human HEPG2, respectively.

Product Specifications

CAS Number

[1018675-35-8]

UNSPSC

12352005

Target

Stearoyl-CoA Desaturase (SCD)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/CVT-12012.html

Purity

99.58

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(NCCN1C(C(C)=NC2=C1C=C(NCC3=CC=CC(C(F)(F)F)=C3)C=C2)=O)CO

Molecular Formula

C21H21F3N4O3

Molecular Weight

434.41

References & Citations

[1]Koltun DO, et al. Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19 (15) :4070-4.|[2]Atkinson KA, et al. N-benzylimidazole carboxamides as potent, orally active stearoylCoA desaturase-1 inhibitors. Bioorg Med Chem Lett. 2011 Mar 15;21 (6) :1621-5.