Ginsenoside Rh2
Ginsenoside Rh2 (20 (S) -Ginsenoside Rh2) induces the activation of caspase-8 and caspase-9. Ginsenoside Rh2 induces cancer cell apoptosis in a multi-path manner.
Product Specifications
CAS Number
78214-33-2
Product Name Alternative
20 (S) -Ginsenoside Rh2; 20 (S) -Rh2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Caspase; Endogenous Metabolite
Type
Natural Products
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Ginsenoside-Rh2.html
Purity
98.87
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C[C@]([C@@](C[C@H]1O)([H])[C@]2(CC[C@@H]3O[C@]([C@@H]([C@@H](O)[C@@H]4O)O)([H])O[C@@H]4CO)C)(CC[C@@]2([H])C3(C)C)[C@]5([C@@]1([H])[C@]([C@@](C)(O)CC/C=C(C)/C)([H])CC5)C
Molecular Formula
C36H62O8
Molecular Weight
622.87
Precautions
H302, H315, H319, H335
References & Citations
[1]Guo XX, et al. p53-dependent Fas expression is critical for Ginsenoside Rh2 triggered caspase-8 activation in HeLa cells. Protein Cell. 2014 Mar;5 (3) :224-34.|[2]Wang M, et al. Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model. Oncol Lett. 2017 Feb;13 (2) :681-685.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Caspase 8; Caspase 9
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