5'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)

5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite blongs to modified antisense oligonucleotide. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite allows the formation of a specific conformation of the furanose ring of the oligonucleotide through the introduction of a cEt modification, enhancing the ability to hybridize to complementary RNA. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is mainly used in the research of regulation of gene expression related to metabolic diseases, cardiovascular diseases, cancers and the development of antisense compounds[1][2].

Product Specifications

CAS Number

[1197033-17-2]

UNSPSC

12352005

Target

Nucleoside Antimetabolite/Analog

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease; Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/5-odmt-cet-n-bzm5-c-phosphoramidite-amidite.html

Purity

99.17

Solubility

DMSO : 175 mg/mL (ultrasonic)

Smiles

CC(C)N(C(C)C)P(OCCC#N)O[C@@H]([C@](O[C@H]1C)([H])[C@H](N2C(N=C(C(C)=C2)NC(C3=CC=CC=C3)=O)=O)O4)[C@@]41COC(C5=CC=C(C=C5)OC)(C6=CC=CC=C6)C7=CC=C(C=C7)OC

Molecular Formula

C49H56N5O9P

Molecular Weight

889.97

References & Citations

[1]Yu J, et al. Synthesis and antisense properties of 2'-O- (2S-methoxypropyl) -RNA-modified gapmer antisense oligonucleotides. ChemMedChem. 2014 Sep;9 (9) :2040-4.|[2]Seth P P, et al. Synthesis and biophysical evaluation of 2′, 4′-constrained 2′ O-methoxyethyl and 2′, 4′-constrained 2′ O-ethyl nucleic acid analogues. The Journal of organic chemistry, 2010, 75 (5) : 1569-1581.