Semaxinib
Semaxinib (SU5416) is a potent and selective inhibitor of VEGFR (Flk-1/KDR) with an IC50 of 1.23 μM[1].
Product Specifications
CAS Number
204005-46-9
Product Name Alternative
SU5416
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SU5416.html
Purity
99.96
Solubility
DMF : 50 mg/mL (ultrasonic) |DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=CC=CC=C/21)C2=C/C3=C(C)C=C(C)N3
Molecular Formula
C15H14N2O
Molecular Weight
238.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Fong TA, et al. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res, 1999, 59 (1), 99-106.|[2]Vajkoczy P, et al. Inhibition of tumor growth, angiogenesis, and microcirculation by the novel Flk-1 inhibitor SU5416 as assessed by intravital multi-fluorescence videomicroscopy. Neoplasia, 1999, 1 (1), 31-41.|[3]Happé CM, et al. Pneumonectomy combined with SU5416 induces severe pulmonary hypertension in rats.Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310 (11) :L1088-97.|[4]Izquierdo-Garcia JL, et al. Metabolic Reprogramming in the Heart and Lung in a Murine Model of Pulmonary Arterial Hypertension. Front Cardiovasc Med. 2018 Aug 15;5:110.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
VEGFR2/KDR/Flk-1
Available Sizes
Frequently Asked Questions
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