JNT-517
JNT-517 is an orally active, selective SLC6A19 allosteric inhibitor with an IC50 of 47 nM for human SLC6A19. JNT-517 can be used for the study of phenylketonuria (PKU) [1].
Product Specifications
CAS Number
2837993-05-0
UNSPSC
12352005
Target
Amino acid Transporter
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/jnt-517.html
Purity
99.00
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(C=C(C=C1)OC(F)(F)F)=C1CNC(N(C2CC2)[C@H]3CN(CCC3)C(N)=O)=O
Molecular Formula
C18H22F4N4O3
Molecular Weight
418.39
References & Citations
[1]Dean G Brown, et al. Small molecule inhibitors of mammalian slc6a19 function. Patent WO2022192370A1. |[2]Wobst HJ, et al., SLC6A19 inhibition facilitates urinary neutral amino acid excretion and lowers plasma phenylalanine. JCI Insight. 2024 Nov 8;9 (21) :e182876.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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