SCH00013
SCH00013 is a cardiotonic that primarily increases the sensitivity of muscle fibers to Ca++.
Product Specifications
CAS Number
217963-18-3
UNSPSC
12352005
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/SCH00013.html
Concentration
10mM
Solubility
DMSO : 32.5 mg/mL (ultrasonic)
Smiles
N#CC1=CC=C(C(O)CN2CC=C(C(CC3)=NNC3=O)CC2)C=C1
Molecular Formula
C18H20N4O2
Molecular Weight
324.38
References & Citations
[2]Tadano N et al. SCH00013, a novel Ca (2+) sensitizer with positive inotropic and no chronotropic action in heart failure. J Pharmacol Sci. 2005 Jan;97 (1) :53-60.|[3]Endoh M et al. Pharmacology of SCH00013: a novel Ca2+ sensitizer. Cardiovasc Drug Rev. 2001 Winter;19 (4) :345-66.|[1]Sugawara H et al. A novel cardiotonic agent SCH00013 acts as a Ca++ sensitizer with no chronotropic activity in mammalian cardiac muscle.
 J Pharmacol Exp Ther. 1998 Oct;287 (1) :214-22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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