SCH00013

SCH00013 is a cardiotonic that primarily increases the sensitivity of muscle fibers to Ca++.

Product Specifications

CAS Number

[217963-18-3]

UNSPSC

12352005

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/SCH00013.html

Concentration

10mM

Solubility

DMSO : 32.5 mg/mL (ultrasonic)

Smiles

N#CC1=CC=C(C(O)CN2CC=C(C(CC3)=NNC3=O)CC2)C=C1

Molecular Formula

C18H20N4O2

Molecular Weight

324.38

References & Citations

[2]Tadano N et al. SCH00013, a novel Ca (2+) sensitizer with positive inotropic and no chronotropic action in heart failure. J Pharmacol Sci. 2005 Jan;97 (1) :53-60.|[3]Endoh M et al. Pharmacology of SCH00013: a novel Ca2+ sensitizer. Cardiovasc Drug Rev. 2001 Winter;19 (4) :345-66.|[1]Sugawara H et al. A novel cardiotonic agent SCH00013 acts as a Ca++ sensitizer with no chronotropic activity in mammalian cardiac muscle. J Pharmacol Exp Ther. 1998 Oct;287 (1) :214-22.