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Fenclonine

Fenclonine is a selective and irreversible tryptophan hydroxylase inhibitor, which is a rate-limiting enzyme in the biosynthesis of serotonin. Fenclonine can be used in carcinoid syndrome research[1][2][3].

Product Specifications

CAS Number

7424-00-2

Product Name Alternative

4-Chloro-DL-phenylalanine; PCPA; CP-10188

UNSPSC

12352005

Hazard Statement

H301, H317

Target

Tryptophan Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/4-Chloro-DL-phenylalanine.html

Purity

99.92

Solubility

1 M NaOH : 150 mg/mL (ultrasonic) |DMSO : 100 mg/mL (ultrasonic; adjust pH to 2 with HCl) |H2O : 4 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC(CC1=CC=C(Cl)C=C1)C(O)=O

Molecular Formula

C9H10ClNO2

Molecular Weight

199.64

Precautions

H301, H317

References & Citations

[1]M Jouvet. Sleep and serotonin: an unfinished story. Neuropsychopharmacology. 1999 Aug;21 (2 Suppl) :24S-27S.|[2]A K Sanyal, et al. Prostaglandins: antinociceptive effect of prostaglandin E1 in the rat. Clin Exp Pharmacol Physiol. 1977 May-Jun;4 (3) :247-55.|[3]Shyamshree S S Manna, et al. Paracetamol potentiates the antidepressant-like and anticompulsive-like effects of fluoxetine. Behav Pharmacol. 2015 Apr;26 (3) :268-81.|[4]Zheng Y, et al. In silico Analysis and Experimental Validation of Lignan Extracts from Kadsura longipedunculata for Potential 5-HT1AR Agonists. PLoS One. 2015 Jun 15;10 (6) :e0130055.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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