VU0364572 (TFA)

VU0364572 TFA is an orally active and selective allosteric agonist of the M1 muscarinic receptor with an EC50 of 0.11 μM. VU0364572 TFA has neuroprotective potential for preventing memory impairments and reducing neuropathology in Alzheimer’s Disease. VU0364572 TFA is CNS penetrant[1][3].

Product Specifications

CAS Number

[1240514-89-9]

Product Name Alternative

WX-UK1; UKI-1C

UNSPSC

12352005

Target

MAChR; MARCKS

Type

Reference compound

Related Pathways

Cytoskeleton; GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vu0364572-tfa.html

Purity

99.27

Solubility

DMSO : 55 mg/mL (ultrasonic)

Smiles

O=C(N1CCC(N2C[C@H](NC(C3=CC=CC=C3C)=O)CCC2)CC1)OCC.O=C(O)C(F)(F)F

Molecular Formula

C23H32F3N3O5

Molecular Weight

487.51

References & Citations

[1]Lebois EP, et al. Disease-Modifying Effects of M1 Muscarinic Acetylcholine Receptor Activation in an Alzheimer's Disease Mouse Model. ACS Chem Neurosci. 2017 Jun 21;8 (6) :1177-1187.|[2]Faruk MO, et al. Muscarinic signaling regulates voltage-gated potassium channel KCNQ2 phosphorylation in the nucleus accumbens via protein kinase C for aversive learning. J Neurochem. 2022 Feb;160 (3) :325-341.|[3]Lebois EP, et al. Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071. Bioorg Med Chem Lett. 2011 Nov 1;21 (21) :6451-5.