MK-0736 (hydrochloride)
MK-0736 hydrochloride is a potent and selective 11β-HSD-1 inhibitor with hypertension-reducing activity. MK-0736 hydrochloride can be used in studies related to metabolic syndrome. MK-0736 hydrochloride has demonstrated good antihypertensive effects and safety in clinical studies[1].
Product Specifications
CAS Number
719274-77-8
UNSPSC
12352005
Target
11β-HSD
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mk-0736-hydrochloride.html
Smiles
O=S(CC)(CCCC12CCC(CC1)(CC2)C3=NN=C(N3C)C4=C(C(F)(F)F)C=CC=C4)=O.Cl
Molecular Formula
C23H31ClF3N3O2S
Molecular Weight
506.02
References & Citations
[1]Sukrut Shah, et al. Efficacy and safety of the selective 11β-HSD-1 inhibitors MK-0736 and MK-0916 in overweight and obese patients with hypertension. J Am Soc Hypertens. 2011 May-Jun;5 (3) :166-76. |[2]Bauman DR, et al. Evaluation of selective inhibitors of 11β-HSD1 for the treatment of hypertension. Bioorg Med Chem Lett. 2013 Jun 15;23 (12) :3650-3.|[3]Efficacy and safety of the selective 11β-HSD-1 inhibitors MK-0736 and MK-0916 in overweight and obese patients with hypertension
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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