Tizoxanide
Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has anti-HIV-1 activities and potent inhibition of both HBV and HCV replication with values EC50 of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells[1][3][4][5].
Product Specifications
CAS Number
173903-47-4
Product Name Alternative
TIZ
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Autophagy; Bacterial; HIV; IKK; Influenza Virus; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Autophagy; NF-κB
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Tizoxanide.html
Purity
98.10
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : < 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=CC=C2O
Molecular Formula
C10H7N3O4S
Molecular Weight
265.25
Precautions
H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
HIV-1
Available Sizes
Frequently Asked Questions
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