N, N'-Diacetylchitobiose

N, N'-Diacetylchitobiose is a dimer of β (1,4) linked N-acetyl-D glucosamine. N, N'-Diacetylchitobiose is the hydrolysate of chitin and can be used as alternative carbon source by E. coli. N, N'-Diacetylchitobiose also reverses myocardial depression[1][2][3][4].

Product Specifications

CAS Number

[35061-50-8]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease; Others

Assay Protocol

https://www.medchemexpress.com/n-n-diacetylchitobiose.html

Purity

99.59

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

O=C[C@H](NC(C)=O)[C@H]([C@@H]([C@@H](CO)O)O[C@H]1[C@H](NC(C)=O)[C@H]([C@@H]([C@@H](CO)O1)O)O)O

Molecular Formula

C16H28N2O11

Molecular Weight

424.40

Precautions

H315, H319

References & Citations

[1]Fangmeng Chu, et al. An optimized cocktail of chitinolytic enzymes to produce N, N'-diacetylchitobiose and N-acetyl-d-glucosamine from defatted krill by-products. Int J Biol Macromol. 2019 Jul 15;133:1029-1034.|[2]Keyhani NO, et al. Wild-type Escherichia coli grows on the chitin disaccharide, N, N'-diacetylchitobiose, by expressing the cel operon. Proc Natl Acad Sci U S A. 1997 Dec 23;94 (26) :14367-71. |[3]Keyhani N O, et al. The Chitin Disaccharide, N, N′-Diacetylchitobiose, Is Catabolized byEscherichia coli and Is Transported/Phosphorylated by the Phosphoenolpyruvate: Glycose Phosphotransferase System. Journal of Biological Chemistry, 2000, 275 (42) : 33084-33090.|[4]Mink S N, et al. N, N′-diacetylchitobiose, an inhibitor of lysozyme, reverses myocardial depression and lessens norepinephrine requirements in Escherichia coli sepsis in dogs. Shock, 2008, 29 (6) : 681-687.