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LU-002i (TFA)

LU-002i TFA is a subunit-selective human proteasome β2c and β2i inhibitor with an IC50 value of 220 nM for β2i[1].

Product Specifications

UNSPSC

12352005

Target

Proteasome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/lu-002i-tfa.html

Smiles

O=C([C@]1(CO1)C)[C@@H](NC([C@@H](NC([C@H](C)NC(CN2CCOCC2)=O)=O)CC3=CC=C(C=C3)OC)=O)CC4C5([H])C(CCCC5)([H])CCC4.OC(C(F)(F)F)=O

Molecular Formula

C37H53F3N4O9

Molecular Weight

754.83

References & Citations

[1]Xin BT, et al. Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits. J Med Chem. 2019 Feb 14;62 (3) :1626-1642.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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