Latent TGF-β1 (human, recombinant)

<strong>Latent TGF-β1 (human, recombinant)</strong>_x000D_ <strong>Catalog number:</strong> B2017324_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 42.4 kDa for LAP-bound TGF-β1_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> −80°C_x000D_ <strong>Keywords:</strong> CED, DPD1, TGFB_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Zhuang X, Zhang H, Li X, Li X, Cong M, Peng F, Yu J, Zhang X, Yang Q, Hu G. Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1 Nat Cell Biol. 2017 Oct;19(10):1274-1285._x000D_ 2: Tschernia NP, Gulley JL. Tumor in the Crossfire: Inhibiting TGF-β to Enhance Cancer Immunotherapy BioDrugs. 2022 Mar;36(2):153-180._x000D_ 3: Karhadkar TR, Meek TD, Gomer RH. Inhibiting Sialidase-Induced TGF-β1 Activation Attenuates Pulmonary Fibrosis in Mice J Pharmacol Exp Ther. 2021 Jan;376(1):106-117._x000D_ 4: Penttinen C, Saharinen J, Weikkolainen K, Hyytiäinen M, Keski-Oja J. Secretion of human latent TGF-beta-binding protein-3 (LTBP-3) is dependent on co-expression of TGF-beta J Cell Sci. 2002 Sep 1;115(Pt 17):3457-68._x000D_ 5: Kim K, Kim YS, Jang JW, Lee GM. Enhancing the production of recombinant human TGF-β1 through an understanding of TGF-β1 synthesis, signaling, and endocytosis in CHO cells Biotechnol J. 2024 Jan;19(1):e2300269._x000D_ 6: Blakytny R, Ludlow A, Martin GE, Ireland G, Lund LR, Ferguson MW, Brunner G. Latent TGF-beta1 activation by platelets J Cell Physiol. 2004 Apr;199(1):67-76._x000D_ 7: Koli K, Hyytiäinen M, Ryynänen MJ, Keski-Oja J. Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts Exp Cell Res. 2005 Nov 1;310(2):370-82._x000D_ 8: Dedobbeleer O, Stockis J, van der Woning B, Coulie PG, Lucas S. Cutting Edge: Active TGF-β1 Released from GARP/TGF-β1 Complexes on the Surface of Stimulated Human B Lymphocytes Increases Class-Switch Recombination and Production of IgA J Immunol. 2017 Jul 15;199(2):391-396._x000D_ 9: Warren J, Im M, Ballesteros A, Ha C, Moore T, Lambert F, Lucas S, Hinz B, Dveksler G. Activation of latent transforming growth factor-β1, a conserved function for pregnancy-specific beta 1-glycoproteins Mol Hum Reprod. 2018 Dec 1;24(12):602-612._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/24821840">10: Alcaraz LB, Exposito JY, Chuvin N, Pommier RM, Cluzel C, Martel S, Sentis S, Bartholin L, Lethias C, Valcourt U. Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-β J Cell Biol. 2014 May 12;205(3):409-28. </a>_x000D_ _x000D_ <strong>Products Related to Latent TGF-β1 (human, recombinant) can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>