CXCL-CXCR1/2-IN-1

CXCL-CXCR1/2-IN-1 is an orally active ELR+CXCL-CXCR1/2 pathway inhibitor with an EC50 of 42.7 nM for CXCR2[1]. CXCL-CXCR1/2-IN-1 shows anticancer and antiangiogenic effects[1].

Product Specifications

CAS Number

[2415653-55-1]

UNSPSC

12352005

Target

CXCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cxcl-cxcr1-2-in-1.html

Purity

99.64

Solubility

DMSO : 4.17 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1=NC2=CC=C([N+]([O-])=O)C=C2S1)NC3=CC(Cl)=CC(Cl)=C3

Molecular Formula

C14H8Cl2N4O3S

Molecular Weight

383.21

References & Citations

[1]Oleksandr Grytsai, et al. A Potent Solution for Tumor Growth and Angiogenesis Suppression via an ELR+CXCL-CXCR1/2 Pathway Inhibitor. ACS Med. Chem. Lett. April 3, 2024.