GNE-6776
GNE-6776 is a selective and orally bioavailable USP7 inhibitor[1].
Product Specifications
CAS Number
[2009273-71-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GNE-6776.html
Purity
98.03
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CCC(C(C1=CC=C(O)C=C1)=C(N)N=C2)=C2C3=CC=C(C(NC)=O)N=C3
Molecular Formula
C20H20N4O2
Molecular Weight
348.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Lorna Kategaya , et al. USP7 Small-Molecule Inhibitors Interfere With Ubiquitin Binding. Nature. 2017 Oct 26;550 (7677) :534-538.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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