L-739749
L-739749 is a farnesyl transferase inhibitor. L-739749 inhibits the selective hypersensitivity of JMML cells to granulocyte-macrophage colony-stimulating factor (GM-CSF) by blocking the prenylation of Ras. L-739749 exhibits a strong inhibitory effect on the growth of primary human JMML cells in vitro[1].
Product Specifications
CAS Number
156511-34-1
UNSPSC
12352005
Target
Farnesyl Transferase; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l-739749.html
Smiles
O=C(OC)[C@@H](NC([C@@H](OC[C@@H](NC[C@@H](N)CS)[C@@H](C)CC)CC1=CC=CC=C1)=O)CCS(=O)(C)=O
Molecular Formula
C24H41N3O6S2
Molecular Weight
531.73
References & Citations
[1]Emanuel P D, et al. Inhibition of juvenile myelomonocytic leukemia cell growth in vitro by farnesyltransferase inhibitors: Presented in part at the Thirty-Ninth American Society of Hematology Meeting, San Diego, CA, December 5-9, 1997[J]. Blood, The Journal of the American Society of Hematology, 2000, 95 (2) : 639-645.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS1086489 Inquire
Recombinant Archaeoglobus fulgidus Uncharacterized protein AF_0761 (AF_0761)
Sign In for Pricing
View Details 