L-739749
L-739749 is a farnesyl transferase inhibitor. L-739749 inhibits the selective hypersensitivity of JMML cells to granulocyte-macrophage colony-stimulating factor (GM-CSF) by blocking the prenylation of Ras. L-739749 exhibits a strong inhibitory effect on the growth of primary human JMML cells in vitro[1].
Product Specifications
CAS Number
156511-34-1
UNSPSC
12352005
Target
Farnesyl Transferase; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l-739749.html
Smiles
O=C(OC)[C@@H](NC([C@@H](OC[C@@H](NC[C@@H](N)CS)[C@@H](C)CC)CC1=CC=CC=C1)=O)CCS(=O)(C)=O
Molecular Formula
C24H41N3O6S2
Molecular Weight
531.73
References & Citations
[1]Emanuel P D, et al. Inhibition of juvenile myelomonocytic leukemia cell growth in vitro by farnesyltransferase inhibitors: Presented in part at the Thirty-Ninth American Society of Hematology Meeting, San Diego, CA, December 5-9, 1997[J]. Blood, The Journal of the American Society of Hematology, 2000, 95 (2) : 639-645.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
