(R) -Elexacaftor
(R) -Elexacaftor is an enantiomer of Elexacaftor (HY-111772) . (R) -Elexacaftor is the Compound 37 from patent WO2018107100A1. (R) -Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR), the EC50 for CFTR dF508 is 0.29 uM[1].
Product Specifications
CAS Number
[2229860-99-3]
Product Name Alternative
(R) -VX-445
UNSPSC
12352005
Target
CFTR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/r-elexacaftor.html
Purity
99.44
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1(C)C[C@@H](C)CN1C2=C(C(NS(C3=CN(C)N=C3C)(=O)=O)=O)C=CC(N4C=CC(OCC(C)(C(F)(F)F)C)=N4)=N2
Molecular Formula
C26H34F3N7O4S
Molecular Weight
597.65
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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