(R) -Elexacaftor

(R) -Elexacaftor is an enantiomer of Elexacaftor (HY-111772) . (R) -Elexacaftor is the Compound 37 from patent WO2018107100A1. (R) -Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR), the EC50 for CFTR dF508 is 0.29 uM[1].

Product Specifications

CAS Number

[2229860-99-3]

Product Name Alternative

(R) -VX-445

UNSPSC

12352005

Target

CFTR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/r-elexacaftor.html

Purity

99.44

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1(C)C[C@@H](C)CN1C2=C(C(NS(C3=CN(C)N=C3C)(=O)=O)=O)C=CC(N4C=CC(OCC(C)(C(F)(F)F)C)=N4)=N2

Molecular Formula

C26H34F3N7O4S

Molecular Weight

597.65

References & Citations

[1]Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator. WO2018107100A1