Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

KY19382

KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC50s of 19 and 10 nM, respectively. KY19382 activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet (HFD) induced metabolic diseases[1][2].

Product Specifications

CAS Number

2226664-93-1

Product Name Alternative

A3051

UNSPSC

12352005

Hazard Statement

H315, H319

Target

GSK-3; Wnt; β-catenin

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ky19382.html

Purity

98.0

Solubility

DMSO : 4.17 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C1NC2=C(C=C(Cl)C(Cl)=C2)/C1=C3NC4=C(C=CC=C4)C/3=N/OC

Molecular Formula

C17H11Cl2N3O2

Molecular Weight

360.19

Precautions

H315, H319

References & Citations

[1]Choi S, et, al. CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth. Life Sci Alliance. 2019 Apr 10; 2 (2) : e201800254.|[2]Choi KY, et, al. Compositions and methods for suppressing and/or treating metabolic diseases and/or a clinical condition thereof. WO2020079569.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

GSK-3β

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

TMIGD1 (NM_206832) Human Over-expression Lysate
LC404232 20 µg

TMIGD1 (NM_206832) Human Over-expression Lysate

Sign In for Pricing
View Details
Recombinant Human FUT8 Protein (aa 68-575, His Tag)
PKSH031148 50 µg

Recombinant Human FUT8 Protein (aa 68-575, His Tag)

Sign In for Pricing
View Details
IGF2 (NM_000612) Human Over-expression Lysate
LC400204 20 µg

IGF2 (NM_000612) Human Over-expression Lysate

Sign In for Pricing
View Details
RAB3IP Mouse Monoclonal Antibody [Clone ID: OTI5D1]
CF808961 100 µg

RAB3IP Mouse Monoclonal Antibody [Clone ID: OTI5D1]

Sign In for Pricing
View Details
PTPRCAP Human Gene Knockout Kit (CRISPR)
KN424803 1 Kit

PTPRCAP Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
Human DENND1B activation kit by CRISPRa
GA116090 1 Kit

Human DENND1B activation kit by CRISPRa

Sign In for Pricing
View Details