CD437

CD437 is a selective Retinoic Acid Receptor γ (RARγ) agonist.

Product Specifications

CAS Number

[125316-60-1]

Product Name Alternative

AHPN

UNSPSC

12352005

Hazard Statement

H302, H400

Target

Autophagy; RAR/RXR

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CD437.html

Purity

98.76

Solubility

DMSO : 150 mg/mL (ultrasonic; warming)

Smiles

O=C(C1=CC=C2C=C(C3=CC=C(O)C(C4(C5)CC6CC5CC(C6)C4)=C3)C=CC2=C1)O

Molecular Formula

C27H26O3

Molecular Weight

398.49

Precautions

H302, H400

References & Citations

[1]Li Y, et al. Molecular determinants of AHPN (CD437) -induced growth arrest and apoptosis in human lung cancer cell lines. Mol Cell Biol. 1998 Aug;18 (8) :4719-31.|[2]Schadendorf D, et al. Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro, and causes growth inhibition in xenografts in vivo. J Cell Biol. 1996 Dec;135 (6 Pt 2) :1889-98.