CD437
CD437 is a selective Retinoic Acid Receptor γ (RARγ) agonist.
Product Specifications
CAS Number
125316-60-1
Product Name Alternative
AHPN
UNSPSC
12352005
Hazard Statement
H302, H400
Target
Autophagy; RAR/RXR
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CD437.html
Purity
98.76
Solubility
DMSO : 150 mg/mL (ultrasonic; warming)
Smiles
O=C(C1=CC=C2C=C(C3=CC=C(O)C(C4(C5)CC6CC5CC(C6)C4)=C3)C=CC2=C1)O
Molecular Formula
C27H26O3
Molecular Weight
398.49
Precautions
H302, H400
References & Citations
[1]Li Y, et al. Molecular determinants of AHPN (CD437) -induced growth arrest and apoptosis in human lung cancer cell lines. Mol Cell Biol. 1998 Aug;18 (8) :4719-31.|[2]Schadendorf D, et al. Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro, and causes growth inhibition in xenografts in vivo. J Cell Biol. 1996 Dec;135 (6 Pt 2) :1889-98.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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