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IFN alpha-IFNAR-IN-1 (hydrochloride)

IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR. IFN alpha-IFNAR-IN-1 hydrochloride inhibits modified Vaccinia virus ankara (MVA) -induced IFN-α responses in murine bone-marrow-derived, Flt3- L-differentiated pDC cultures (BM-pDCs) (IC50=2-8 μM) [1].

Product Specifications

CAS Number

[2070014-98-9]

UNSPSC

12352005

Target

IFNAR

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/IFN-alpha-IFNAR-IN-1-hydrochloride.html

Purity

99.76

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic)

Smiles

CNCC1=CC=CC=C1SC2=C(C=CC=C3)C3=CC=C2.[H]Cl

Molecular Formula

C18H18ClNS

Molecular Weight

315.86

References & Citations

[1]Geppert T, et al. Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions. Angew Chem Int Ed Engl. 2012 Jan 2;51 (1) :258-61.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Adv Healthc Mater. 2023 May;12 (13) :e2202830.|Arthritis Res Ther. 2022 Jul 19;24 (1) :170.|Biochem Biophys Res Commun. 2025 Nov 1:787:152767.|bioRxiv. 2025 Aug 12.|Cell Death Dis. 2020 Dec 11;11 (12) :1050.|Cell Mol Life Sci. 2022 Jan 20;79 (2) :83.|Cell Rep. 2023 Feb 28;42 (3) :112145.|Cell Rep. 2024 Apr 23;43 (4) :114088.|Clin Exp Immunol. 2021 Apr;204 (1) :64-77.|Exp Eye Res. 2021 Jan;202:108375.|Front Immunol. 2019 Oct 11;10:2391.|J Med Virol. 2023 Nov;95 (11) :e29237.|J Virol. 2025 Jan 23:e0153924.|Mol Oncol. 2023 Dec;17 (12) :2584-2602.|Nature. 2022 Sep;609 (7928) :785-792.|Pharmacol Res. 2023 Jan:187:106615.|PLoS Pathog. 2022 Feb 14;18 (2) :e1010301.|Viruses. 2022 Aug 18;14 (8) :1806.|Arthritis Rheumatol. 2020 Jun;72 (6) :1003-1012.|Cell Rep. 2022 Nov 29;41 (9) :111738.|Free Radic Biol Med. 2022 Nov 20;193 (Pt 1) :202-212.|Front Immunol. 2019 May 3:10:980.|Sci Rep. 2016 Jul 14;6:29665.

Available Sizes

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