Taltobulin (trifluoroacetate)

Taltobulin trifluoroacetate (HTI-286 trifluoroacetate), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin trifluoroacetate inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis[1].

Product Specifications

CAS Number

[228266-41-9]

Product Name Alternative

HTI-286 trifluoroacetate; SPA-110 trifluoroacetate

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Payload; Apoptosis; Microtubule/Tubulin

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Taltobulin-trifluoroacetate.html

Concentration

10mM

Purity

99.08

Solubility

DMSO : ≥ 39 mg/mL

Smiles

CC(C)(C)[C@H](NC([C@H](C(C)(C1=CC=CC=C1)C)NC)=O)C(N([C@@H](C(C)C)/C=C(C(O)=O)\C)C)=O.O=C(O)C(F)(F)F

Molecular Formula

C29H44F3N3O6

Molecular Weight

587.67

Precautions

H302, H315, H319, H335

References & Citations

[1]Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63 (8) :1838-45.