Taltobulin (trifluoroacetate)
Taltobulin trifluoroacetate (HTI-286 trifluoroacetate), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin trifluoroacetate inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis[1].
Product Specifications
CAS Number
228266-41-9
Product Name Alternative
HTI-286 trifluoroacetate; SPA-110 trifluoroacetate
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Payload; Apoptosis; Microtubule/Tubulin
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Taltobulin-trifluoroacetate.html
Concentration
10mM
Purity
99.08
Solubility
DMSO : ≥ 39 mg/mL
Smiles
CC(C)(C)[C@H](NC([C@H](C(C)(C1=CC=CC=C1)C)NC)=O)C(N([C@@H](C(C)C)/C=C(C(O)=O)\C)C)=O.O=C(O)C(F)(F)F
Molecular Formula
C29H44F3N3O6
Molecular Weight
587.67
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Traditional Cytotoxic Agents
Available Sizes
Frequently Asked Questions
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