Lucidone

Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE2 production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC50=25 μM) [1][2].

Product Specifications

CAS Number

[19956-53-7]

UNSPSC

12352005

Hazard Statement

H315-H319

Target

COX; Dengue Virus; Flavivirus; IKK; JNK; NF-κB; NO Synthase; p38 MAPK; TNF Receptor

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/lucidone.html

Solubility

10 mM in DMSO

Smiles

OC(/C=C/C1=CC=CC=C1)=C2C(C(OC)=CC\2=O)=O

Molecular Formula

C15H12O4

Molecular Weight

256.25

Precautions

P264-P280-P302+P352-P305+P351+P338-P362+P364

References & Citations

[1]Senthil Kumar KJ, et aL. Lucidone inhibits iNOS and COX-2 expression in LPS-induced RAW 264.7 murine macrophage cells via NF-kappaB and MAPKs signaling pathways. Planta Med. 2009 Apr;75 (5) :494-500. |[2]Chen WC, et al. Lucidone suppresses dengue viral replication through the induction of heme oxygenase-1. Virulence. 2018 Jan 1;9 (1) :588-603.