Absinthin

Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca2+-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46[1][2][3].

Product Specifications

CAS Number

[1362-42-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Natural Products

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/absinthin.html

Purity

98.0

Solubility

DMSO : 5 mg/mL (ultrasonic; warming)

Smiles

CC1=C[C@@]2([H])[C@]3([H])[C@]1([C@](OC4=O)([H])[C@@]([C@@H]4C)([H])CC[C@@]3(O)C)[C@]5([H])[C@@]2([H])[C@]([C@]6(O)C)([H])C([C@](OC7=O)([H])[C@@]([C@@H]7C)([H])CC6)=C5C

Molecular Formula

C30H40O6

Molecular Weight

496.64

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhang W, et al. Total synthesis of absinthin. J Am Chem Soc. 2005 Jan 12;127 (1) :18-9.|[2]Lachenmeier DW, et al. Absinthe--a review. Crit Rev Food Sci Nutr. 2006;46 (5) :365-77.|[3]Talmon M, et al. Absinthin, an agonist of the bitter taste receptor hTAS2R46, uncovers an ER-to-mitochondria Ca2+-shuttling event. J Biol Chem. 2019 Aug 16;294 (33) :12472-12482.|[4]Guo N, et al. Absinthin attenuates LPS-induced ALI through MIP-1α-mediated inflammatory cell infiltration. Exp Lung Res. 2015;41 (9) :514-24. |[5]Talmon M, et al. Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells. J Nat Prod. 2020 Jun 26;83 (6) :1740-1750.