Hypericin

Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450) . Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis[1][2][3].

Product Specifications

CAS Number

[548-04-9]

UNSPSC

12352005

Hazard Statement

H302, H317

Target

Antibiotic; Apoptosis; Cytochrome P450; Dopamine β-hydroxylase; Influenza Virus; Monoamine Oxidase; PKC; Reverse Transcriptase; Telomerase

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Neuronal Signaling; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Hypericin.html

Purity

98.03

Solubility

DMSO : 250 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=C(O)C=C(O)C3=C2C4=C(C5=C6C(O)=CC(C)=C5C7=C4C1=C(O)C=C7C)C8=C3C(O)=CC(O)=C8C6=O

Molecular Formula

C30H16O8

Molecular Weight

504.44

Precautions

H302, H317

References & Citations

[1]A Kubin, et al. Hypericin--the facts about a controversial agent. Curr Pharm Des. 2005;11 (2) :233-53.|[2]A Popovic, et al. Differential susceptibility of primary cultured human skin cells to hypericin PDT in an in vitro model. J Photochem Photobiol B. 2015 Aug;149:249-56.|[3]Renata Sanovic, et al. Low dose hypericin-PDT induces complete tumor regression in BALB/c mice bearing CT26 colon carcinoma. Photodiagnosis Photodyn Ther. 2011 Dec;8 (4) :291-6.