Azetidine-2-carboxylic acid

Azetidine-2-carboxylic acid is a non proteinogenic amino acid homologue of proline. Found in common beets. Azetidine-2-carboxylic acid can be misincorporated into proteins in place of proline in many species, including humans. Toxic and teratogenic agent[1][2].

Product Specifications

CAS Number

[2517-04-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Azetidine-2-carboxylic_acid.html

Purity

98.0

Solubility

10 mM in DMSO|H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(O)C1NCC1

Molecular Formula

C4H7NO2

Molecular Weight

101.10

Precautions

H302, H315, H319, H335

References & Citations

[1]Rubenstein E, et al. Azetidine-2-carboxylic acid in the food chain. Phytochemistry. 2009 Jan;70 (1) :100-4.|[2]Rubenstein E, et al. Misincorporation of the proline analog azetidine-2-carboxylic acid in the pathogenesis of multiple sclerosis: a hypothesis. J Neuropathol Exp Neurol. 2008 Nov;67 (11) :1035-40.|[3]Lane JM, et al. Effect of the proline analogue azetidine-2-carboxylic acid on collagen synthesis in vivo. I. Arrest of collagen accumulation in growing chick embryos. Biochim Biophys Acta. 1971 Jun 29;236 (3) :517-27.