BMY-14802 (hydrochloride)

BMY-14802 hydrochloride (BMY-14802-1) is a selective and orally active sigma receptor antagonist with an IC50 of 112 nM. BMY-14802 hydrochloride is also a 5-HT1A and adrenergic α1 receptors agonist. BMY-14802 hydrochloride has antipsychotic effects[1][2][3].

Product Specifications

CAS Number

[105565-55-7]

Product Name Alternative

BMY-14802-1; BMS 181100 (hydrochloride)

UNSPSC

12352005

Target

5-HT Receptor; Adrenergic Receptor; Sigma Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bmy-14802-hydrochloride.html

Purity

98.02

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

[H]Cl.OC(C1=CC=C(F)C=C1)CCCN2CCN(C3=NC=C(F)C=N3)CC2

Molecular Formula

C18H23ClF2N4O

Molecular Weight

384.85

References & Citations

[1]J P Yevich, et al. Synthesis and biological characterization of alpha- (4-fluorophenyl) -4- (5-fluoro-2-pyrimidinyl) -1-piperazinebutanol and analogues as potential atypical antipsychotic agents. J Med Chem. 1992 Nov 27;35 (24) :4516-25.|[2]Nirmal Bhide, et al. The effects of BMY-14802 against L-DOPA- and dopamine agonist-induced dyskinesia in the hemiparkinsonian rat. Psychopharmacology (Berl) . 2013 Jun;227 (3) :533-44.|[3]Melanie A Paquette, et al. The sigma-1 antagonist BMY-14802 inhibits L-DOPA-induced abnormal involuntary movements by a WAY-100635-sensitive mechanism. Psychopharmacology (Berl) . 2009 Jul;204 (4) :743-54.