AKR1C1-IN-1

AKR1C1-IN-1 is a potent and selective inhibitor of human 20α-hydroxysteroid dehydrogenase (AKR1C1), with a Ki value of 4 nM for AKR1C1[1].

Product Specifications

CAS Number

[4906-68-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/akr1c1-in-1.html

Purity

99.38

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(C2=CC=CC=C2)=CC(Br)=C1O)O

Molecular Formula

C13H9BrO3

Molecular Weight

293.11

Precautions

H302, H315, H319, H335

References & Citations

[1]El-Kabbani O, et al. Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) . J Med Chem. 2009 May 28;52 (10) :3259-64.