Tivozanib
Tivozanib (AV-951; KRN951) is a selective, orally active inhibitor for vascular endothelial growth factor receptor (VEGFR) -1, 2 3, with IC50s of 30, 6.5 and 15 nM, respectively. Tivozanib exhibits antitumor efficacy[1].
Product Specifications
CAS Number
475108-18-0
Product Name Alternative
AV-951; KRN951
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Tivozanib.html
Purity
99.80
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(C=C1Cl)OC2=CC=NC3=CC(OC)=C(C=C23)OC)NC4=NOC(C)=C4
Molecular Formula
C22H19ClN4O5
Molecular Weight
454.86
Precautions
H302, H315, H319, H335
References & Citations
[1]Nakamura K, et al., KRN951, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, has antitumor activities and affects functional vascular properties. Cancer Res. 2006 Sep 15;66 (18) :9134-42.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4
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