Metalaxyl-M

Metalaxyl-M ((R) -Metalaxyl) is an orally active and selective inhibitor of fungal RNA polymerase, which exerts fungicidal activity by selectively interfering with the synthesis of fungal ribosomal RNA. Metalaxyl-M can also be used to induce inflammation in hepatocytes and regulate tryptophan metabolism. Metalaxyl-M can be used in ecotoxicology studies[1][2][3].

Product Specifications

CAS Number

[70630-17-0]

Product Name Alternative

(R) -Metalaxyl

UNSPSC

12352005

Hazard Statement

H302, H318

Target

DNA/RNA Synthesis; Fungal

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/metalaxyl-m.html

Purity

98.09

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

C[C@H](C(OC)=O)N(C1=C(C)C=CC=C1C)C(COC)=O

Molecular Formula

C15H21NO4

Molecular Weight

279.33

Precautions

H302, H318

References & Citations

[1]Yinjun Zhang, et al. Bio-preparation of (R) -DMPM using whole cells of Pseudochrobactrum asaccharolyticum WZZ003 and its application on kilogram-scale synthesis of fungicide (R) -metalaxyl. Biotechnol Prog|[2]OuYang MN, et al. The different toxic effects of metalaxyl and metalaxyl-M on Tubifex tubifex. Ecotoxicol Environ Saf. 2021 Jan 15;208:111587.|[3]Zhang P, et al. Identifying Metabolic Perturbations and Toxic Effects of Rac-Metalaxyl and Metalaxyl-M in Mice Using Integrative NMR and UPLC-MS/MS Based Metabolomics. Int J Mol Sci. 2019 Nov 1;20 (21) :5457.