EN523
EN523 is a OTUB1 recruiter. EN523 targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1[1].
Product Specifications
CAS Number
[2094893-05-5]
UNSPSC
12352005
Hazard Statement
H301, H311, H331, H341
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/en523.html
Purity
99.22
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
C=CC(N1CCN(C(C1)=O)C2=CC=C(O2)C)=O
Molecular Formula
C12H14N2O3
Molecular Weight
234.25
Precautions
H301, H311, H331, H341
References & Citations
[1]Henning NJ, et al. Deubiquitinase-targeting chimeras for targeted protein stabilization. Nat Chem Biol. 2022;18 (4) :412-421.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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