SNX7886
SNX7886 is a potent protac degrader of CDK8/19. SNX7886 degrades CDK 8 and CDK 19 with 90% and 80% degradation in 293 cells, respectively[1].
Product Specifications
CAS Number
2924557-42-4
UNSPSC
12352005
Target
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/snx7886.html
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=C(C(N1C3C(NC(CC3)=O)=O)=O)C(NCCCC(NCCCCCCCCCCC(N4CCN(CC4)C(CN5N=CC(C6=CC=C(C7=C8C=CC=CC8=CN=C7)C=C6)=C5)=O)=O)=O)=CC=C2
Molecular Formula
C52H59N9O7
Molecular Weight
922.08
References & Citations
[1]Chen M, et al. CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins. Nucleic Acids Res. 2023 Aug 11;51 (14) :7288-7313
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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