AC-264613

AC-264613 is a potent and selective protease-activated receptor (PAR-2) agonist with a pEC50 of 7.5[1].

Product Specifications

CAS Number

[1051487-82-1]

UNSPSC

12352005

Target

Protease Activated Receptor (PAR)

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ac-264613.html

Purity

98.3

Solubility

10 mM in DMSO|DMSO : ≥ 40mg/mL

Smiles

O=C(N/N=C(C1=CC=CC(Br)=C1)\C)[C@H]2[C@@H](CNC2=O)C3=CC=CC=C3

Molecular Formula

C19H18BrN3O2

Molecular Weight

400.27

References & Citations

[1]Jimmi Gerner Seitzberg, et al. Discovery of potent and selective small-molecule PAR-2 agonists. J Med Chem. 2008 Sep 25;51 (18) :5490-3.|[2]Rui Yamaguchi, et al. A protease-activated receptor 2 agonist (AC-264613) suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages: Role of p53. Cell Biol Int. 2016 Jun;40 (6) :629-41.|[3]Luis R Gardell, et al. Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J Pharmacol Exp Ther. 2008 Dec;327 (3) :799-808.