AC-264613
AC-264613 is a potent and selective protease-activated receptor (PAR-2) agonist with a pEC50 of 7.5[1].
Product Specifications
CAS Number
[1051487-82-1]
UNSPSC
12352005
Target
Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ac-264613.html
Purity
98.3
Solubility
10 mM in DMSO|DMSO : ≥ 40mg/mL
Smiles
O=C(N/N=C(C1=CC=CC(Br)=C1)\C)[C@H]2[C@@H](CNC2=O)C3=CC=CC=C3
Molecular Formula
C19H18BrN3O2
Molecular Weight
400.27
References & Citations
[1]Jimmi Gerner Seitzberg, et al. Discovery of potent and selective small-molecule PAR-2 agonists. J Med Chem. 2008 Sep 25;51 (18) :5490-3.|[2]Rui Yamaguchi, et al. A protease-activated receptor 2 agonist (AC-264613) suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages: Role of p53. Cell Biol Int. 2016 Jun;40 (6) :629-41.|[3]Luis R Gardell, et al. Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J Pharmacol Exp Ther. 2008 Dec;327 (3) :799-808.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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