ICA 110381
ICA 110381 is an orally active Kv7.2/Kv7.3 (KCNQ2/3) potassium channel activator with anticonvulsive properties. ICA 110381 is a KCNQ2/Q3 activator (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM) [1].
Product Specifications
CAS Number
325457-99-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ica-110381.html
Purity
99.85
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(Cl)N=C1)C2=CC=C(Cl)C=C2
Molecular Formula
C12H8Cl2N2O
Molecular Weight
267.11
Precautions
H302, H315, H319, H335
References & Citations
[1]Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2 (6) :481-4.|[2]A Boehlen, et al. The new KCNQ2 activator 4-Chlor-N- (6-chlor-pyridin-3-yl) -benzamid displays anticonvulsant potential. Br J Pharmacol. 2013 Mar;168 (5) :1182-200.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Voltage-gated potassium channel
Available Sizes
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