ICA 110381

ICA 110381 is an orally active Kv7.2/Kv7.3 (KCNQ2/3) potassium channel activator with anticonvulsive properties. ICA 110381 is a KCNQ2/Q3 activator (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM) [1].

Product Specifications

CAS Number

[325457-99-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ica-110381.html

Purity

99.85

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(Cl)N=C1)C2=CC=C(Cl)C=C2

Molecular Formula

C12H8Cl2N2O

Molecular Weight

267.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2 (6) :481-4.|[2]A Boehlen, et al. The new KCNQ2 activator 4-Chlor-N- (6-chlor-pyridin-3-yl) -benzamid displays anticonvulsant potential. Br J Pharmacol. 2013 Mar;168 (5) :1182-200.