Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

ICA 110381

ICA 110381 is an orally active Kv7.2/Kv7.3 (KCNQ2/3) potassium channel activator with anticonvulsive properties. ICA 110381 is a KCNQ2/Q3 activator (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM) [1].

Product Specifications

CAS Number

325457-99-6

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ica-110381.html

Purity

99.85

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(Cl)N=C1)C2=CC=C(Cl)C=C2

Molecular Formula

C12H8Cl2N2O

Molecular Weight

267.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2 (6) :481-4.|[2]A Boehlen, et al. The new KCNQ2 activator 4-Chlor-N- (6-chlor-pyridin-3-yl) -benzamid displays anticonvulsant potential. Br J Pharmacol. 2013 Mar;168 (5) :1182-200.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Voltage-gated potassium channel

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Frozen Tissue Sections, Breast
CS621128 5x 5 µm

Frozen Tissue Sections, Breast

Sign In for Pricing
View Details
FOXO1 antibody
FNab10255 100 µg

FOXO1 antibody

Sign In for Pricing
View Details
CLN5 Rabbit Polyclonal Antibody
TA372251 100 µL

CLN5 Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
OR6C76 Human Gene Knockout Kit (CRISPR)
KN423717 1 Kit

OR6C76 Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
CD34 Class I Mouse Monoclonal Antibody [Clone ID: B-G25]
AM31234AF-N 200 µg

CD34 Class I Mouse Monoclonal Antibody [Clone ID: B-G25]

Sign In for Pricing
View Details
Luzindole
TRC-L482000-25MG 25 mg

Luzindole

Sign In for Pricing
View Details