K67
Product Specifications
UNSPSC Description
K67 specifically inhibits the interaction between Keap1 and S349-phosphorylated p62. K67 prevents p-p62 from blocking the binding of Keap1 and Nrf2. K67 effectively inhibits the proliferation of HCC cultures with high cellular S351-phosphorylated p62 by restoring the ubiquitination and degradation of Nrf2 driven by Keap1[1].
Target Antigen
Keap1-Nrf2; p62
Type
Reference compound
Related Pathways
Autophagy;NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/k67.html
Purity
98.43
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(CC1=CC(NS(C2=CC=C(OCC)C=C2)(=O)=O)=C3C=CC=CC3=C1NS(C4=CC=C(OCC)C=C4)(=O)=O)=O
Molecular Weight
582.69
References & Citations
[1]Saito T, et al. p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming. Nat Commun. 2016 Jun 27;7:12030.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-111126/K67-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-111126/K67-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2046250-48-8
Available Sizes
Curated Selection
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