NA-184
NA-184 is a selective and brain-penetrant calpain-2 inhibitor with an IC50 of 134 nM for mouse calpain-2. NA-184 has weak inhibitory activity on calpain-1 (IC50 of 2826 nM) . NA-184 does not exhibit significant inhibition on a variety of other cysteine-, serine- or metallo-proteases. NA-184 shows significant neuroprotection and can be used for the study of traumatic brain injury (TBI) [1].
Product Specifications
CAS Number
[2688119-39-1]
UNSPSC
12352005
Target
Proteasome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/na-184.html
Purity
99.66
Solubility
DMSO : ≥ 100 mg/mL
Smiles
ClC1=CC=CC(CNC(C(C(CC)NC([C@H](CC(C)C)NC(NCC2=CC=CC=C2)=O)=O)=O)=O)=C1OC
Molecular Formula
C27H35ClN4O5
Molecular Weight
531.04
References & Citations
[1]Baudry M, et al. Identification and neuroprotective properties of NA-184, a calpain-2 inhibitor. Pharmacol Res Perspect. 2024 Apr;12 (2) :e1181.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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