MK-571
MK-571 (L-660711) is an orally active, potent and selective competitive leukotriene D4 (LTD4) receptor antagonist, with Ki values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 is also a MRP4 and ABCC1 (MRP1) inhibitor. MK-571 inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release[1][2][3].
Product Specifications
CAS Number
115104-28-4
Product Name Alternative
L-660711
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Leukotriene Receptor; LPL Receptor; P-glycoprotein
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/MK-571.html
Concentration
10mM
Purity
98.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)CCSC(C1=CC=CC(/C=C/C2=NC3=CC(Cl)=CC=C3C=C2)=C1)SCCC(N(C)C)=O
Molecular Formula
C26H27ClN2O3S2
Molecular Weight
515.09
Precautions
H302, H315, H319, H335
References & Citations
4
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LTD4/CysLT1; LTE4
Citation 01
Available Sizes
Frequently Asked Questions
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