AMPK activator 2 (hydrochloride)
AMPK activator 2 (compound 7a) hydrochloride, a fluorine-containing proguanil derivative, up-regulates AMPK signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 hydrochloride inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549) [1].
Product Specifications
UNSPSC
12352005
Target
AMPK
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ampk-activator-2-hydrochloride.html
Purity
99.65
Solubility
DMSO : ≥ 100 mg/mL
Smiles
N=C(NC(NC1=CC=C(C(F)(F)F)C=C1)=N)NCC(C)C.[H]Cl
Molecular Formula
C13H19ClF3N5
Molecular Weight
337.77
References & Citations
[1]Di Xiao, et al. Synthesis, biological evaluation and anti-proliferative mechanism of fluorine-containing proguanil derivatives. Bioorg Med Chem. 2020 Jan 15;28 (2) :115258.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPK
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC040943-500 1x 500 µL
Rabies (Rab-50), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
