1-Linoleoyl Glycerol

1-Linoleoyl glycerol is a LpPLA2 inhibitor. 1-Linoleoyl glycerol acts as a precursor for synthesizing various functional lipids, such as phospholipids. 1-Linoleoyl glycerol mitigates inflammation induced by Apolipoprotein CIII (reduction of IL-6) [1][2][3].

Product Specifications

CAS Number

[2277-28-3]

Product Name Alternative

1-Linoleoyl-rac-glycerol; 1-Monolinolein

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Apolipoprotein; Interleukin Related; Phospholipase

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/1-Linoleoyl_Glycerol.html

Purity

98.0

Solubility

DMSO : ≥ 100 mg/mL|Ethanol : 100 mg/mL (ultrasonic)

Smiles

CCCCC/C=C\C/C=C\CCCCCCCC(OCC(O)CO)=O

Molecular Formula

C21H38O4

Molecular Weight

354.52

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Lee WS, et al. Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis roots. Bioorg Med Chem Lett. 2005 Aug 1;15 (15) :3573-5.|[2]Archambault AS, et al. Biosynthesis of the Novel Endogenous 15-Lipoxygenase Metabolites N-13-Hydroxy-octodecadienoyl-ethanolamine and 13-Hydroxy-octodecadienoyl-glycerol by Human Neutrophils and Eosinophils. Cells. 2021 Sep 5;10 (9) :2322.|[3]Duan H, et al. Dose-dependent effect of Dendrobium officinale polysaccharide on anti-aging in Caenorhabditis elegans: A metabolomics analysis focused on lipid and nucleotide metabolism regulation. Food Bioscience, 2024, 61: 104615.