α-Methyltyrosine methyl ester (hydrochloride)

α-Methyltyrosine methyl ester hydrochloride is an orally active and competitive tyrosine hydroxylase inhibitor. α-Methyltyrosine methyl ester hydrochloride can inhibit the conversion of tyrosine to dopamine. α-Methyltyrosine methyl ester hydrochloride causes kidney damage and urethral calculi in rats. α-Methyltyrosine methyl ester hydrochloride can be used as a tool for sympathetic nervous system research[1].

Product Specifications

CAS Number

[7361-31-1]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Thyroid Hormone Receptor; Tyrosine Hydroxylase

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/α-methyltyrosine-methyl-ester-hydrochloride.html

Purity

98.91

Solubility

DMSO : 4.55 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 10 mg/mL (ultrasonic)

Smiles

NC(CC1=CC=C(C=C1)O)(C)C(OC)=O.[H]Cl

Molecular Formula

C11H16ClNO3

Molecular Weight

245.71

Precautions

H302, H315, H319, H335

References & Citations

[1]G Magnusson, et al. Renal lesions induced by alpha-methyltyrosine methylester and alpha-methyltyrosine. Acta Pharmacol Toxicol (Copenh) . 1970;28 (6) :435-44.