PKC/PKD-IN-1
PKC/PKD-IN-1 (Compound 13C) is an orally active dual protein kinase C/D (PKC/PKD) inhibitor with an IC50 value of 0.6 nM for PKD1. PKC/PKD-IN-1 can attenuate high-salt diet-induced cardiac hypertrophy and can be used in the study of heart failure[1].
Product Specifications
CAS Number
[1071135-06-2]
UNSPSC
12352005
Target
PKC; PKD
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; TGF-beta/Smad
Applications
Neuroscience-Neurodegeneration
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pkc-pkd-in-1.html
Purity
98.35
Solubility
10 mM in DMSO
Smiles
C1(NC2CCCCC2)=NC=CC(C3=CC4=C(C(N5CCNCC5)=N3)C=CN=C4)=C1
Molecular Formula
C23H28N6
Molecular Weight
388.51
References & Citations
[1]Meredith EL, et al. Identification of orally available naphthyridine protein kinase D inhibitors. J Med Chem. 2010;53 (15) :5400-5421.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKD1
Available Sizes
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