TNIK-IN-9
TNIK-IN-9 (Compound 54) is a selective and potent NIK inhibitor, with an IC50 of 1.27 nM. TNIK-IN-9 can inhibit pro-inflammatory cytokines and nitric oxide production. TNIK-IN-9 exhibits significant anti-inflammatory effects, improved mortality, and hepatoprotective effects in sepsis models[1].
Product Specifications
UNSPSC
12352005
Target
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tnik-in-9.html
Solubility
10 mM in DMSO
Smiles
O[C@@](C1=NC=CS1)(C#CC2=NN3C(N(CCC3)C4=CC=NC(NC5=CC6=C(C=C5)OCO6)=N4)=C2)C
Molecular Formula
C24H21N7O3S
Molecular Weight
487.53
References & Citations
[1]Zhang N, et al. Design, Synthesis, and Biological Evaluation of a Novel NIK Inhibitor with Anti-Inflammatory and Hepatoprotective Effects for Sepsis Treatment. J Med Chem. 2024 Apr 11;67 (7) :5617-5641.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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