Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Amdiglurax

Amdiglurax (NSI-189) is an orally active chemical entity with enhanced neurogenic activity. Amdiglurax up-regulates neurogenic factors such as BDNF (brain derived-neurotrophic factor) and SCF. Amdiglurax exhibits anti-depressant effect. Amdiglurax enhances synaptic plasticity and reduces cognitive dysfunction. Amdiglurax holds potential for psychiatric disorder research[1][2][3].

Product Specifications

CAS Number

1270138-40-3

Product Name Alternative

NSI-189

UNSPSC

12352005

Hazard Statement

H302

Target

Trk Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nsi-189.html

Purity

99.57

Solubility

10 mM in DMSO|DMSO : 110 mg/mL (ultrasonic)

Smiles

O=C(N1CCN(CC2=CC=CC=C2)CC1)C3=CC=CN=C3NCCC(C)C

Molecular Formula

C22H30N4O

Molecular Weight

366.50

Precautions

H302

References & Citations

[1]McIntyre RS, et al. The neurogenic compound, NSI-189 phosphate: a novel multi-domain treatment capable of pro-cognitive and antidepressant effects. Expert Opin Investig Drugs. 2017 Jun;26 (6) :767-770. |[2]Tajiri N, et al. NSI-189, a small molecule with neurogenic properties, exerts behavioral, and neurostructural benefits in stroke rats. J Cell Physiol. 2017 Oct;232 (10) :2731-2740. |[3]Jolivalt CG, et al. Amelioration of Both Central and Peripheral Neuropathy in Mouse Models of Type 1 and Type 2 Diabetes by the Neurogenic Molecule NSI-189. Diabetes. 2019 Nov;68 (11) :2143-2154.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

HOMER2 Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI1D1]
TA806246BM 100 µL

HOMER2 Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI1D1]

Sign In for Pricing
View Details
CMBL Human qPCR Primer Pair (NM_138809)
HP217085 200 Reactions

CMBL Human qPCR Primer Pair (NM_138809)

Sign In for Pricing
View Details
PRAMEF16 (NM_001045480) Human Over-expression Lysate
LC420754 20 µg

PRAMEF16 (NM_001045480) Human Over-expression Lysate

Sign In for Pricing
View Details
AKT1 Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI3E3]
TA504231BM 100 µL

AKT1 Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI3E3]

Sign In for Pricing
View Details
DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/2564R), CF640R conjugate, 0.1mg/mL
BNC402564-100 1x 100 µL

DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/2564R), CF640R conjugate, 0.1mg/mL

Sign In for Pricing
View Details
AMBP Antibody
KC-172-01 50 μL

AMBP Antibody

Sign In for Pricing
View Details