RD162
RD162, a diarylthiohydantoin, is an orally active non-steroidal antiandrogen (NSAA) . RD162 specifically binds to androgen receptor (AR) . RD162 induces tumor regression in mouse models of castration-resistant human prostate cancer[1].
Product Specifications
CAS Number
915087-27-3
UNSPSC
12352005
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rd162.html
Purity
99.69
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NC)C1=CC=C(N(C(N(C2=CC=C(C#N)C(C(F)(F)F)=C2)C3=O)=S)C43CCC4)C=C1F
Molecular Formula
C22H16F4N4O2S
Molecular Weight
476.45
References & Citations
[1]Chris Tran, et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science. 2009 May 8;324 (5928) :787-90.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
M2355-01L-PE 200 µL
MAPKAP Kinase 2, phosphorylated (Ser272) (Mitogen-activated Protein Kinase-activated Protein Kinase 2, MAP Kinase-activated Protein Kinase 2, MAPK-activated Protein Kinase 2, MAPKAPK2, MAPKAPK-2, MK2) (PE) discontinued
Sign In for Pricing
View Details 
36974061 1.0 µg DNA
PLEKHA3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
Sign In for Pricing
View Details 15200121 3x 1.0µg DNA
CCDC137 CRISPRa sgRNA lentivector (set of three targets)(Human)
Sign In for Pricing
View Details NB300-317AF405 0.1 mL
Rabbit Polyclonal xCT Antibody [Alexa Fluor 405]
Sign In for Pricing
View Details